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This might be explained by the abstinence of hookah smoking for 12 h prior to testing, thereby reducing nicotine levels drastically in the system, which would impact neuro-hormonal regulation (reduced cortisol and sympathetic activity)

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Because they burn for up to two hours, your oral membranes are exposed to a sustained, heavy absorption track

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The amount of nicotine consumed during accidental ingestions is not a known, leading to increases in potential toxicity