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Rodrick notes, sans appropriate citation, in the new Rolling Stone

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Just like in Beetlejuice, I needed somebody to ground the movie so it wouldnt spring off into the stratosphere. Ryder described the look of her character, Kim, as reminding her of the girls who bullied her in highschool, but Burton was right

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Our analysis relies on modelled estimates of smoking-attributable mortality from GBD 2019, which come with uncertainty intervals (addressed by our upper- and lower-bound sensitivity analysis) and inherently assume that smoking is the primary differentiating factor between the smoker and non-smoker groups