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This can include: Autoimmune disorders (including systemic lupus erythematosus) Bleeding disorders Cancer of the mouth Infections such as hand-foot-mouth disease Weakened immune system -- for example, if you have AIDS or are taking medicine to suppress your immune system after a transplant Drugs that may cause mouth sores include aspirin, beta-blockers, chemotherapy medicines, penicillamine, sulfa drugs, and phenytoin

Smoking during pregnancy and breastfeeding is definitely harmful and comes with its fair share of risks

doi:10.1080/09595230801927372

The scientific answer is: Nicotine itself does NOT cause a false positive for amphetamines, THC, cocaine, or opioids

The proceedings from that first workshop constituted an overview of the possibilities