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This is a common fear among new cigar smokers in particular

Adaptive trials can make the most efficient use of resources [18] by potentially allowing conclusions to be reached more quickly, and requiring smaller sample sizes on average than traditional trial designs, or avoiding unnecessary use of resources conducting underpowered trials

however, the sidestream yields of other analytes were found to decrease with increasing tobacco mass (e.g

The lung cancers that occur in never-smokers are genetically simpler, says Rudin

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