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The dose-response relationship between smoking and cardiovascular mortality is non-linear, suggesting that reduction in HPHC concentrations in e-cigarette aerosols may not result in proportional harm reduction and decreased HPHC exposure may be offset by increased use by individuals who believe that e-cigarettes are safer than conventional cigarettes

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The researchers concluded that RJR (at the time operating as RJR Nabisco) was just as effective at reaching children as the Disney Channel

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