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RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis

What to Do If One Medication Isn't Working Well Enough If Mounjaro or Wegovy alone reaches a dose ceiling without satisfactory results, your doctor has several evidence-based options: continue escalating the single agent to its maximum recommended dose, switch to a different drug class (such as SGLT2 inhibitors or older lipase inhibitors), or consider a combination approved by clinical evidencesuch as metformin plus GLP-1 therapy for patients with prediabetes

Rolland PH, Friggi A, Barlatier A, Piquet P, Latrille V, Faye MM, Guillou J, Charpiot P, Bodard H, Ghiringhelli O, Calaf R, Luccioni R, and Garon D (1995)

Archived from the original on 25 February 2021