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It was co-written and directed by Terry Gilliam and stars Johnny Depp and Benicio del Toro as Raoul Duke and Dr

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Research has shown that the cardiovascular system reacts almost immediately to tobacco smoke even one cigarette. Doctor Wylie added that while someone smoking 20 a day is at far greater risk, the physical effects begin with the very first cigarette. She went on to say: If someone were to smoke a single cigarette, the immediate effects on the body would include a transient rise in heart rate and blood pressure, constriction of blood vessels, and a temporary reduction in oxygen delivery due to carbon monoxide exposure. The doctor has also touched on the longer-term concerns of smoking that also come into play: Even low-level smoking increases the risk of cancers of the lung, mouth, throat and oesophagus, and when combined with alcohol in social settings, the carcinogenic effects are amplified. However, its not all doom and gloom