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A total of 54.8% (17/31) of the observations reported effect sizes for chewing tobacco broadly, with the remainder defining their exposure as the use of a specific chewing tobacco product, including betel quid with tobacco (5/31)

They make it possible to represent smoking in a credible manner, while protecting the health of the actors

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Does smoking cause more chronic pain, or do more women take up smoking as a coping mechanism for experiencing chronic pain?" Mannino describes acute pain as a "protective response" and theorizes that perhaps female smokers experience acute pain that develops into chronic pain because their normal protection and mechanisms are damaged by exposure to smoke

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