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However, as IVW can be sensitive to heterogeneity and horizontal pleiotropy, we performed additional sensitivity analyses using complementary MR methods, including MR-Egger regression, the weighted median method, and the weighted mode estimator, to evaluate the robustness of our findings and to account for potential violations of the MR assumptions

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Archived from the original on 5 August 2009

In fact, it has been shown that cigarette smoking significantly modifies the composition of intestinal microbiota by favoring the presence of opportunistic pathogens such as some species of Enterobacteriaceae and the phylum Bacteroidetes (82)

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