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2 Methods 2.1 Literature search PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) were searched, using keywords such as Chronic obstructive pulmonary disease, Mitochondrial dysfunction, Mitochondrial quality control, Mitophagy, Mitochondrial dynamics, Mitochondrial biogenesis, Therapeutic strategies to retrieve studies in ameliorating COPD by targeting mitochondria

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Pipe smokers absorb nicotine through oral mucosa even without lung inhalation, maintaining dependence and making cessation difficult

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