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I think our work is super exciting because we had the power to directly examine the effects of smoking in tissues such as lung and colon, which are highly relevant in the pathophysiology of smoking. Understanding defense mechanisms to smoke Many of the CpGs identified in the tissues matched up with ones identified in previous studies using blood samples, including genes involved in detoxification or transformation of foreign chemicals so they can be removed from the body

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doi: 10.1016/j.tox.2011.05.015

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