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For example, San Marcos, California , passed an ordinance requiring any shop that sells tobacco products, including e-cigarettes and related devices, to purchase a city-issued tobacco retail license. The city partnered with the San Marcos Prevention Coalition and the Vista Community Clinic, which conducted surveys of local e-cigarette retailers and vape shops and determined that a number of businesses were selling these products to minors in violation of state law

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ten of them were synonymous variants and five of them were missense mutations (Table 5)

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