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Toxicants present in CS and e-vapor increase secretion of ROS that can further induce cell stress responses, such as proinflammatory pathways, unfolded protein response pathways, and alterations in cell differentiation, including goblet cell hyperplasia [71]

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As a member country of the FCTC, South Korea has strengthened regulations on e-cigarettes and HTPs in line with the increasing obligation to comply with the treaty and the growing preference for e-cigarettes among young people, along with a continuous increase in the sales volume of e-cigarettes and HTPs 12

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