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AEs frequently lead to premature treatment discontinuation, with studies showing that nausea and psychiatric symptoms are primary reasons for varenicline discontinuation, resulting in reduced smoking cessation success rates by up to 30%, 15 while poor medication adherence is significantly associated with treatment failure across all smoking cessation pharmacotherapies

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Once this tripartite division is recalled, tobaccos relation to the soul becomes clear: the three prevalent types of smoking tobacco-cigarettes, cigars, and pipes-correspond to the three parts of the soul