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In the third step, we extracted age group-specific RR data and relevant bias covariates from the studies identified in our systematic review approach of age-specific smoking risk on CVD outcomes, and used MR-BRT to model the age pattern of excess risk (that is, RR-1) of smoking on CVD outcomes with age group-specific excess RR data for all CVD outcomes

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A 2015 study published in the Lancet found that Chinese men smoke a third of all the cigarettes in the world, and that by the year 2050, three million of them will die each year of smoking-related causes