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The smokingrelated prostate cancer data analyzed in this study were obtained from GBD 2021, which are derived from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, satellite imaging, and disease notifications, and provide the burden of 371 diseases and injuries in 21 GBD regions and 204 countries and territories over the period 1990 to 2021 (included 32 time points) from updated epidemiological data estimates 12-15

Principal component analysis (PCA) demonstrated distinct metabolic differences between NIC and CON mice, while partial recovery of testicular metabolites was observed in CES mice (Fig

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