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345 doi: (Published 25 October 2012) Cite this as: BMJ 2012;345:e7093 R Sakata, associate senior scientist1, P McGale, senior statistician2, E J Grant, assistant department chief1, K Ozasa, department chief1, R Peto, professor2, S C Darby, professor2 1 Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan 2 Clinical Trial Service Unit, University of Oxford, Oxford OX3 7LF, UK Correspondence to: S C Darby sarah ctsu.ox.ac.uk Accepted 17 October 2012 Abstract Objective To investigate the impact of smoking on overall mortality and life expectancy in a large Japanese population, including some who smoked throughout adult life

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