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Nomenclature ABTS 2,2Azinobis(3ethylbenzthiazoline6sulphonic acid) ADC Arginine decarboxylase AntiTMV Antitobacco mosaic virus CHT Chemma tobacco DPPH 2,2Diphenyl1picrylhydrazylhydrate EPC Endothelial progenitor cells FRAP Ferric reducing antioxidant power JAT1 and JAT2 Jasmonateinducible alkaloid transporters 1 and 2 IARC International Agency for Research on Cancer MATE 1 and 2 Multidrug and toxic compound extrusion 1 and 2 MRSA Methicillinresistant Staphylococcus aureus nAChRs Nicotinic acetylcholine receptors NCI National Cancer Institute NUP1 Nicotine uptake permease 1 OGD Oxygenglucose deprivation PAH Polycyclic aromatic hydrocarbons SLT Smokeless tobacco ST Smoking tobacco TNF Tumor necrosis factoralpha TSNAs Tobaccospecific nitrosamines USDA United States Department of Agriculture WHO World Health Organization Author Contributions Comprehensive literature review, writingoriginal draft, visualization, and revision and editing the manuscript: Abir Chami