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We did not assess costs to health care systems, but others have established that stop-smoking programs are cost-effective.56 64 Feasibility, acceptability, and equity Feasibility Behavioural and pharmacotherapy smoking cessation interventions are commonly provided in primary care in Canada, and e-cigarettes are already used by many people for smoking cessation

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We excluded some meta-analyses from Cochrane reviews (e.g., bupropion, NRT) because they included some RCTs with active controls, and we applied a strict placebo or usual care control criterion