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Although the CAPRIE trial demonstrated that clopidogrel versus aspirin reduced the relative risk of major adverse cardiovascular events by 8.7% in favor of clopidogrel, yet the absolute risk reduction was small with a number needed to treat (NNT) of 200, without difference in amputation rate between treatment groups [93]

Population of NSW adults sourced from ABS Estimate Resident Population Figures.

National Youth Tobacco Survey, 2014

Next, three multivariate regression models, each accounting for the effects of age and gender and year of diagnosis, are shown in Table 1

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