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One of the most compelling concerns about teenagers and e-cigarettes, however, is related to nicotine, a highly addictive chemical that has also been shown to negatively affect brain development, particularly the cerebral cortex and hippocampus, the parts of the brain that are responsible for decision-making and impulse control

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Few doubt that nicotine is addictive

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It has been suggested that such decreased mesolimbic activity causes a lack of abil- ity to experience pleasure (i.e., anhedo- nia) and that this effect is involved in drug dependence