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Damage to the protective epithelial tissue from smoking only increases the prolonged retention of insoluble polonium 210 compounds produced from burning tobacco

Unlike Nicotine Replacement Therapy (NRT) products, there is no clinical trial evidence showing e-cigarettes safety and effectiveness in smoking cessation

Although its not proven, some have speculated that this masking can sometimes lead users to take more profound or more frequent puffs than they otherwise would, which might slightly increase the risk of throat irritation, especially in novice users

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