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These materials must be tested for comprehension in a representative sample of the population and must provide a clear understanding that (i) the best choice for a smoker is to quit, (ii) the cMRTP is not risk free, (iii) the cMRTP is addictive as it contains nicotine, and (iv) the cMRTP is not an alternative to quitting

But California weighed those risks against long-term public health costs and chose to move forward

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and due to restricted oxygen delivery, there is reduced cardiac work, increase in heart rate, blood pressure, and cardiac contractility