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Because the combustible cigarette smoke and e-cigarette aerosol that people inhale doesnt have direct contact with the blood vessels, and the blood does, we took blood serum (the clear liquid in blood that remains after it clots) from every participant and put it in contact with endothelial cells in a culture dish to evaluate how the different serum samples affected the functional behavior of those cells. Springer said

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As time goes on, the dosage of nicotine in NRT is reduced gradually, until your body no longer craves it

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In abstainers who smoked, normalization of the cholinergic system takes approximately 3 months, but structural and functional recovery requires a longer period of time [64]