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The research design, methods, findings, and conclusions of the studies were then examined to evaluate the physiological effects, clinical application, controversies, and safety of the application of ozone in musculoskeletal medicine

Cancer Res 64:57675774 Myzak MC, Hardin K, Wang R et al (2006) Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells

Cells produce ROS during normal aerobic respiration, and superoxide dismutase (SOD) in the cells catalyzes the conversion of superoxide anions (O 2 ) into hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ), thereby detoxifying ROS

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Using transcriptomic, chemical and biochemical approaches, we discover that rather than directly targeting bacteria, KL1 consistently reduces host ROS/RNS