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Acknowledgements We thank Professor David Nutt and Professor Stephan Ripke for their helpful comments on the manuscript

Research on the Contribution of Sugars to the Levels of Harmful Constituents in Product Emissions Combustion of Tobacco Cigarettes Approximately 0.5% of the sugars present in tobacco are transferred into mainstream smoke, whereas the major part will undergo pyrolysis or participate in pyrosynthesis (i.e., formation of new chemicals from multiple precursors)

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