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Nicotine, the primary addictive component of tobacco, acts on nicotinic acetylcholine receptors in the brain, leading to the release of dopamine and other neurotransmitters associated with pleasure and reward

Lake James, a power-generating reservoir in western North Carolina, is named for him

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Table 4.18A Numbers (in Thousands) of Persons Who Initiated Cigarette Use in the United States, Their Mean Age at First Use, and Rates at First Use (Per 1,000 Person-Years of Exposure): 1965-2003, Based on 2002-2004 NSDUHs