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Many of these particles contain varying amounts of toxic chemicals that have been linked to heart and respiratory diseases and cancer

The percentage RR of smoking ten cigarettes per week were calculated using figures from the largest and most recent meta-analyses, case-control, or cohort studies available describing the risk of smoking according to frequency of cigarettes smoked, and where the primary end point was cancer incidence (Additional file 1: Table S5)

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In recent years, several subfamilies of RBR E3 ubiquitin ligases have been identified, including the Ariadne family, which includes Ariadne homolog 1 (ARIH1), ARIH2, PARkin-like cytoplasmic protein (PARC), and ankyrin repeat and IBR domain-containing protein 1 (Ankib1) and has the Ariadne domain

Worldwide smoking has emerged as the leading cause of death and the reason for numerous cancers