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Bonnie Springs at Hines Hospital, VA Medical Center, gave depressed and non-depressed subjects either nicotinized or denicotinized cigarettes after introducing a positive mood trigger and found that [s]elf-administering nicotine appears to improve depression-prone smokers emotional response to a pleasant stimulus. To investigate further, researchers at the University of Pittsburgh studied whether or not cigarettes improve emotional response to stressful triggers such as preparing for public speaking, dealing with a difficult computer task, and seeing negative images

Figure 2 shows how widely and intensely nicotine can bind to the acetylcholine receptors in the brain

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A 2023 study of trends in nicotine strength among e-cigarette products found that the average concentration of nicotine in e-cigarettes has increased from 2.5% to 4.4% between 2017 and 2022

PLoS One 15 , e0235276