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The agencys continued review does not alter the fact that all e-cigarette products, including those made by JUUL, are required by law to have FDA authorization to be legally marketed. As of the end of May, the FDA says it has only authorized 23 e-cigarette products and devices after the products have undergone what the FDA says is rigorous scientific review that includes toxicologic assessments

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According to a study by Everitt and Wolf titled Psychomotor Stimulant Addiction: A Neural Systems Perspective, published in the Journal of Neuroscience (2002), chronic stimulant exposure results in long-lasting neural adaptations in the prefrontal cortex, reducing cognitive flexibility and increasing susceptibility to compulsive drug-seeking behaviors