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The guaranteed delivery via injection bypasses the absorption issues that tirzepatide creates in the GI tract

AZZAROLI F, MENNONE A, FELETTI V, SIMONI P, BAGLIVO E, MONTAGNANI M, RIZZO N, PELUSI G, DE ALOYSIO D, LODATO F, FESTI D, COLECCHIA A, RODA E, BOYER J , MAZZELLA G

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This protective effect can be partly mediated by DC-derived IL-10, as its selective deletion in DCs exacerbated cisplatin nephrotoxicity [19]