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Thiamine is a key component of oxidative glucose metabolism, sitting at the entry point of the TCA cycle as a cofactor for the pyruvate dehydrogenase complex (PDH)

Arch Neurol 46 : 543548 Vogel DG, Malekzadeh MH, Cornford ME, Schneider JA, Shields WD, Vinters HV 1990 Central nervous system involvement in nephropathic cystinosis

40 Therefore, the interaction between antioxidants and iNOS/COX-2 presents a possible target for inflammation management

Novel results in microbiome studies suggest that microbial metabolic products are common factors that determine health or disease conditions (77)

Fosgonimeton failed its Phase 2 ACT-AD trial in 2022 and its Phase 2/3 LIFT-AD trial in September 2024