Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan adc making the linkers highly adaptable

making the linkers highly adaptable for diverse ADC and related applications

a synthetic antibiotic

Product Name Thalidomide-O-PEG3-C2-acid Synonyms Thalidomide-4'-O-PEG3-C2-acid CAS Number 2324154-35-8 Related CAS Molecular Formula C22H26N2O10 Molecular Weight 478

626 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCCCCN)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

S)-AHPC-acetamido-O-PEG1-OH Synonyms CAS Number n/a Related CAS Molecular Formula C26H36N4O6S Molecular Weight 532

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan adc making the linkers highly adaptableSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,