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PMID: 40263302 Cell Death Dis 2025 Apr 14;16(1):293

The treated group received 25,000 IU per day retinyl palmitate for 6 months followed by 10,000 IU per day retinyl palmitate for another 6 months

Pharmacokinetic analysis in this trial revealed a critical association between drug exposure and toxicityhigher drug exposure was associated with a higher incidence of oral ulcers ( P = 0.047), and this was more pronounced in patients requiring dose reduction [117]highlighting the importance of balancing efficacy and safety through therapeutic drug monitoring

Similarly, a short-term intravenous infusion with amino acids in young, human volunteers induced temporary insulin resistance [22]

Obes Res 11:311312