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The median interval between the paired biopsies was 4.75 years (range 0.7-23.8)

& Cravatt, B

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreichs ataxia

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One of the most vulnerable brain regions to normal age-related and disease related alterations in BBB permeability is the hippocampus (Sweeney et al., 2018a