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Another NAM analog-based NNMT inhibitor, 6-methoxy NAM (also known as JBSNF000088), has shown promise in decreasing body weight and enhancing insulin sensitivity in mice models of obesity induced by a high-fat diet 198

Glutathione depletion, especially in the liver, commonly occurs as a side eect of the use of opioids for anesthesia and during drug abuse, resulting in the accumulation of reactive oxygen species and concomitant liver and kidney damage

Naito Y, Takagi T, Higashimura Y

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