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This ultimately enhances the stability of Nrf2 expression, thereby inhibiting oxidative stress-induced lysosomal membrane permeabilization (LMP) and the senescence of nucleus pulposus cells (NPCs), offering a novel epigenetic strategy for treating IVDD [148]

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Inactivation of the IGF-I gene in mice results in perinatal lethality

Institutional Review Board Statement The study was conducted in accordance with the Declaration of Helsinki, and approved by the Research Ethics Committee of Ain Shams University (protocol code ACUC-FP-ASU-RHDIRB20202110301 REC NO