Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Product Name: 5(6) - CR110

Product Name: 5(6) - CR110 Synonyms: [5 - (and - 6) - Carboxyrhodamine 110 CAS Number: N/A Molecular Formula: C21H14N2O5 Molecular Weight: 374

Product Name Pomalidomide-PEG4-OH Synonyms Pomalidomide-4'-PEG4-OH CAS Number  2140807-23-2 Related CAS Molecular Formula C21H27N3O8 Molecular Weight 449

46 SMILES OCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

261 SMILES FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=NN=NN2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Product Name: 5(6) - CR110SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating