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Toxicology 229 , 3341

In the context of ER stress, the RIDD pathway plays a cytoprotective role, while IRE1 promotes the production of XBP1s, which in turn promotes the expression of genes beneficial to ER stress recovery (Shishova et al., 2022)

It helps to neutralize free radicals and reduce oxidative stress, which are major contributors to premature aging

Stress and other factors can prolong this phase, leading to increased hair loss

38 Other studies have similarly identified many novel germline NF1 mutations across the length of the NF1 coding region with no evidence of mutational hotspots