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doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al

Certain bacteria or yeasts can convert histidine into histamine in the body, triggering an allergic reaction

All but the most severe of cases can be successfully managed through lifestyle changes in diet and physical activity alone, although low compliance has encouraged interest in effective therapies, including gastrointestinal surgery (efficacious and long-lasting, but limited in use because of associated risks and costs) and pharmacological interventions

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Its bacteriostatic properties make it particularly advantageous for long-term storage and repeated use, minimizing the risk of contamination