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References 1 Abdi SarabiM.ShiriA.AghapourM.ReichardtC.BrandtS.MertensP

Caffeic acid is well-documented to induce apoptosis via mitochondrial pathways and cell cycle arrest in breast cancer cells through ROS modulation 70,82

only hydrolyzed by thioesterases after entering cells

The specific targeting and removal of mitochondria by autophagy, i.e., mitophagy, is achieved by the pathways of phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin, and by many other proteins in the mitochondrial membrane or the cytosol [848586878889]

The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update