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Animal model studies consistently show that pharmacological inhibition of ferroptosis or genetic upregulation of GPX4 expression leads to significantly reduced MMP and ADAMTS expression in cartilage tissue, accompanied by marked improvement in cartilage structural integrity (Dong et al., 2025

Since then, advancements have been made in understanding its causes and treatment options for this debilitating condition

Weve explained it in detail here, but in a nutshell, stress and anxiety cause our bodies to produce more stress hormones (like cortisol) which, if produced over a prolonged period, can cause increased inflammation and tissue hypersensitivity

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Methods Human neutrophil isolation Human neutrophils were isolated from normal donor blood by Ficoll density centrifugation, as previously described 67