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A third biological function of the HIFs is the reprogramming of cellular metabolism by inducing a transition from aerobic to anaerobic metabolism

The ketone ester, 3-hydroxybutyl-3-hydroxybutyrate, attenuates neurobehavioral deficits and improves neuropathology following controlled cortical impact in male rats

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All mutants were outcrossed at least twice with the wild type to eliminate background mutations

To improve strategies aimed at reinvigorating exhausted CD8 + T cells, including anti-PD therapy, defining the developmental biology of exhausted CD8 + T cells and determining which T-cell cluster primarily responds to anti-PD therapy are particularly important