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BH4 is a strong antioxidant that sequesters radicals and, either by itself or in combination with vitamin E, prevents lipid membranes from undergoing autoxidation (189).The transsulfuration pathway, mevalonate pathway, ferroptosis inhibitory protein 1 (FSP1)-coenzyme Q10 (CoQ10) pathway, dihydroorotate dehydrogenase (DHODH)-dihydroubiquione (CoQH2) pathway, and GTP cyclohydrolase-1 (GCH1)-tetrahydrobiopterin (BH4) pathway are among the other antioxidant systems that have also been linked to the regulation of ferroptosis (190) ( Figure 5 )

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Ethics statement The animal study was approved by Changzhi Medical College's Experimental Animal Care & Use Committee

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Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed according to Reitman and Frankel