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However, it is important to emphasize the fact that the skin is the only organ exposed to the external environment, especially areas such as the face, neck, hands, and arms, which reflect both chronological and photoaging [9]

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Theres a wide range of symptoms presented from severe DPYD deficiency (two copies of the DPYD mutations).[ref] On one end of the spectrum, DPYD mutations are associated with delayed development, epilepsy, learning disability, growth retardations, and autism

Dysregulated nocturnal cortisol rhythms interfere with slow-wave oscillations and sleep spindles during non-rapid eye movement (NREM) sleep, thereby exacerbating the severity of insomnia