Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg 51 SMILES OCCOCCOCCOCCOCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

51 SMILES OCCOCCOCCOCCOCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

85 SMILES Cl

this construct supports efficient antibody conjugation

1038/nature18621

OC(=O)C(F)(F)F

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:1mg 51 SMILES OCCOCCOCCOCCOCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing