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In this context, adenosine assumes the role of a local hormone: cell metabolism is adjusted via low- or high-affinity purinergic receptors expressed by immune and bone cells as well as by tumor cells

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SNPs in three genes, namely, folylpoly--glutamate synthase ( FPGS ), -glutamyl hydrolase ( GGH ), and folate carrier ( SLC19A1 ), have been reported as potential predictors of toxicities and efficacy after therapy with pemetrexed [9, 10, 17]

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