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LC-MS/MS is widely regarded as a gold standard due to its inherent sensitivity, specificity, and capability for simultaneous quantification of multiple vitamins and their metabolites from limited sample volumes, which is particularly advantageous in pediatric CF patients (Konieczna et al., 2016

-Acetolactate is synthesized as an intermediate in the 2-ketoisovalerate pathway or produced from acetaldehyde by Ilv2p (Figure 1) (Suomalainen and Ronkainen 1968)

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Nevertheless, strategies to optimise cognitive performance during sport are highly desirable, and nutritional interventions are acknowledged as a potential means of boosting cognitive performance during exercise (Reference Meeusen128)