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[DOI] [PubMed] [Google Scholar] 3.Li Q, Geng X, Zheng W, Tang J, Xu B, Shi Q

Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)

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