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Results: A total of 997 children with MASLD, with a mean age of 12.82.9 years, were followed for an average of 6.14.2 years, totaling 6,120 person-years

Furthermore, niacin binds to the G-protein-coupled hydroxycarboxylic acid receptor 2, which is upregulated in a proinflammatory environment and which may downregulate inflammation (164166)

Nonetheless, overall SCFA depletion (as seen with low-fiber diets or dysbiosis) is generally associated with worse outcomes in aging and neurodegeneration due to loss of their beneficial gut and brain effects

doi: 10.1016/j.neures.2018.09.002 33

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